Constance had been in post since May 2016
The Scottish Government cabinet secretary with responsibility for the third sector has quit.
Angela Constance, secretary for communities, social security and equalities, has written to First Minister Nicola Sturgeon to confirm she is stepping down from her post.
She joins health secretary Shona Robison in making an exit as Sturgeon reshuffles her cabinet.
The First Minister has paid tribute to their work in government and will announce her new cabinet later this afternoon.
Constance, a Lothian MSP and former education secretary, had been in post since May 2016, taking over from Alex Neil.
Following her resignation, she tweeted: "Been a privilege to serve nearly 8 years @scotgov, proud of my work to increase youth employment & the steps taken to end child poverty. Good luck to my successor & other colleagues - I’m looking forward to spending summer in my fantastic constituency and with my wee boy."
John Downie, director of public affairs at the Scottish Council for Voluntary Organisations (SCVO), said: "Angela Constance has been a great friend of Scotland’s third sector over the eight years she’s been a member of the Scottish Government and she will be missed by SCVO and our members.
"Although Angela’s most recent cabinet position saw her work extremely closely with the sector - on issues like community empowerment and social security - she has always sought to include Scotland’s charities and voluntary organisations in her work and the work of the government; including in her previous roles in education, skills and youth and women’s employment.
"It’s clear to all those who have worked with Angela that she has a passion for helping people and making a real and lasting difference to Scotland’s communities.
"We look forward to continuing our excellent relationship with Angela as MSP for Almond Valley."
Minister for international development and Europe Dr Alasdair Allan, minister for community safety and legal affairs Annabelle Ewing and minister for mental health Maureen Watt will also be leaving the government.
